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The aim of this examine should be to characterize the metabolites of EAM-2201 in human hepatocytes obtained in vitro and those in liver and urine specimens acquired in vivo through the autopsy of the EAM-2201 abuser.
Twelve metabolites of a synthetic cannabinoid, here EAM-2201, were tentatively discovered in human hepatocytes in vitro, and in human liver and urine specimens in vivo for the first time. There was a definite variation in metabolism profile amongst the in vitro and in vivo success.
EAM-2201 was incubated with human hepatocytes for three h within a CO2 incubator and also the metabolites of EAM-2201 ended up made. The human liver specimen was homogenized and the metabolites ended up extracted. The urine specimen was hydrolyzed initial with β-glucuronidase plus the metabolites had been extracted.
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The most effective product was determined employing Akaike’s information criterion being a measure of goodness of fit. The inhibition method was confirmed by visual inspection of Lineweaver–Burk plots of enzyme kinetic information provided by Enzyme Kinetics software package.
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